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Antibody drugs consist of antibody or antibody substances, which are prepared by antibody engineering technology based on cell and gene engineering technology. There are two main types of antibodies, one is monoclonal antibody, another is polyclonal antibody. Monoclonal antibody is generated by identical B cells and only recognize the same epitope of an antigen, and thus have monovalent affinity. Polyclonal antibody usually produced by different B cell clones in the body and can recognize many different epitopes of a single antigen. Therefore, antibody drugs have many incomparable advantages, such as the high specificity, affinity, and efficiency. CD BioSciences provides comprehensive services on antibody drugs development with professional technology, extensive experience, and advanced equipment, including but not limited to Antibody Preparation Services, phage display services, antibody-drug conjugates, bispecific antibody services, and antibody humanization services.
Phage display is an exogenous gene expression method in which the gene encoding the protein of interest is inserted into the phage coat protein gene, and then the protein of interest is displayed on the surface of the phage to achieve the connection between genotype and phenotype. Antibody phage display library has distinct advantages on discovering novel monoclonal antibodies and even the fully human antibody. Antibody Humanization Service. With phage display services of CD BioSciences, you can get your antibodies in less than 2 months. Our antibody library various species and in various formats (Fab, scFv, or others), which promises the quality and speed of your antibody development. According to the different properties and advantages, CD BioSciences offers the most appropriate phage display system for your demands.
Preparation the Fully Human Antibody
Human phage antibody libraries for antibody screening can be constructed with antibody genes amplified from human B lymphocytes.
High Biopanning Efficiency
Antibodies with high specificity will be obtained in 2 weeks with 2-4 rounds of panning.
Wide Application
Phage display technology has broad applications in antibody preparation areas, including but not limited targeting tumor, autoantigen, toxic antigen, and highly conservative antigen.
Antibody-drug Conjugates (ADC), as a type of highly targeted Biotechnological drugs, delivers highly active or potent pharmaceutical ingredients to targeted cells with monoclonal antibodies or other biologics. The advantage of ADC is to combine the benefits of both therapeutic monoclonal antibodies (mAb) and potent small molecule cytotoxic drugs. CD BioSciences offers comprehensive services on antibody-drug conjugates, covering antibody engineering, drug development, antibody-drug conjugate, and evaluation services. We provide specific services to solve your problems on ADC. Welcome to inquire us for more details.
Bispecific antibodies (BsAb) are antibodies, consisting of fragments of two different monoclonal antibodies, and thus it can bind two different antigens or different epitopes of the same antigen. The widest application of BsAb is in cancer immunotherapy. Simply, BsAb redirects cytotoxic immune effector cells to increase killing of tumor cells by antibody-dependent cell-mediated cytotoxicity and other cytotoxic mechanisms mediated by the effector cells. Generally, there are two classes of BsAb, those with an Fc region and those without an Fc region. BsAb without an Fc region always are smaller than those with an Fc region. CD BioSciences has various technical platforms on antibody development including bispecific antibody development and BsAb formats to meet your experimental demands on ideal BsAbs design and development.
Murine monoclonal antibodies account for a large proportion of therapeutic antibodies in clinical use, while murine monoclonal antibodies always are prone to HAMA reaction (human anti-mouse antibody reaction), which causes risks for patients. HAMA reaction limits application of murine monoclonal antibodies. Given that, it is a practical solution to humanize murine antibody in order to expand the therapeutic use of mouse derived antibodies. Antibody Humanization is an indispensable step for the development of all therapeutic antibodies which derived from non-human sources. CD BioSciences provides comprehensive services on antibody Humanization from antigen to clinically relevant solution, including in silico optimization, in silico humanization, high-throughput antibody screening, humanized antibody characterization, humanized antibody affinity determination. CD BioSciences offers the most appropriate antibody humanization service for your experimental demands.
