Introduction
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is encoded by the ADAMTS1 gene in humans. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as the development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
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Direction of Drugs Discovery
• ADAMTS1 Inhibitor
• Developing New Clinical Effects on ADAMTS1 from Existing Drugs
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Drugs
• ADAMTS1 Inhibitor- PMID16516466C12c